Non-Targeted Sequencing Identification System Secures Milestone C and Full-Rate Production

In August, the Portfolio Acquisition Executive for Layered Protection and Integration (PAE LP&I)’s Joint Project Manager for CBRN Integrated Early Warning (JPM CBRN IEW) secured Milestone C (MS C) and Full-Rate Production (FRP) for the Non-Targeted Sequencing Identification System (NSIS). The NSIS provides rapid biological sequencing that identifies biological warfare agents and endemic pathogens of concern. With the program entering the Production & Deployment (P&D) phase, JPM CBRN IEW is one step closer to delivering on-site genomic sequencing to the National Guard Bureau, U.S. Navy and U.S. Army. New Equipment Training (NET) is scheduled to begin in November 2026.

PAE LP&I’s partners at the U.S. Army Combat Capabilities Development Command (DEVCOM) Chemical Biological Center (CBC) provided scientific rigor behind the sequencing protocols and analysis software, while the Office of the Deputy Assistant Secretary of War for Chemical, Biological, Radiological and Nuclear Defense (ODASW(CBRND)) funded the program and provided strategic oversight. A joint effort between PAE LP&I, DEVCOM CBC, ODASW(CBRND), industry partners, end users and other stakeholders enabled the program to reach MS C and FRP.

The NSIS will enhance warfighters’ biological agent identification capability in the field, improving command decision-making at the speed of relevance.

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